zardaverine (CHEBI:46548)

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ChEBI Name	zardaverine

ChEBI ID	CHEBI:46548

Definition	A pyridazinone derivative in which pyridazin-3(2H)-one is substituted at C-6 with a 4-(difluoromethoxy)-3-methoxyphenyl group. It is a phosphodiesterase inhibitor, selective for PDE3 and 4.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C12H10F2N2O3

Net Charge

Average Mass

268.21620

Monoisotopic Mass

268.06595

InChI

InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)

InChIKey

HJMQDJPMQIHLPB-UHFFFAOYSA-N

SMILES

COc1cc(ccc1OC(F)F)-c1ccc(=O)[nH]n1

Roles Classification
Biological Role(s):	EC 3.1.4.* (phosphoric diester hydrolase) inhibitor An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a phosphoric diester hydrolase (EC 3.1.4.*).

Application(s):	peripheral nervous system drug A drug that acts principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system. anti-asthmatic drug A drug used to treat asthma. bronchodilator agent An agent that causes an increase in the expansion of a bronchus or bronchial tubes.

ChEBI Ontology
Outgoing	zardaverine (CHEBI:46548) has role anti-asthmatic drug (CHEBI:49167) zardaverine (CHEBI:46548) has role bronchodilator agent (CHEBI:35523) zardaverine (CHEBI:46548) has role EC 3.1.4.* (phosphoric diester hydrolase) inhibitor (CHEBI:50218) zardaverine (CHEBI:46548) has role peripheral nervous system drug (CHEBI:49110) zardaverine (CHEBI:46548) is a organofluorine compound (CHEBI:37143) zardaverine (CHEBI:46548) is a pyridazinone (CHEBI:26414)

IUPAC Name

6-[4-(difluoromethoxy)-3-methoxyphenyl]pyridazin-3(2H)-one

Synonyms	Sources
6-(4-(Difluoromethoxy)-3-methoxyphenyl)-3(2H)-pyridazinone	ChemIDplus
6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE	PDBeChem

Registry Number	Type	Source
101975-10-4	CAS Registry Number	ChemIDplus

Last Modified

25 February 2016