CHEBI:78330 - huperzine A

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ChEBI Name huperzine A
ChEBI ID CHEBI:78330
Definition A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 3.1.1.7 (acetylcholinesterase) inhibitor
An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
plant metabolite
Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via alkaloid )
Application(s): neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
nootropic agent
Any compound that improves mental functions such as cognition, memory, intelligence, motivation, attention, and concentration.
Related Structures
huperzine A is a Structural Derivative of
sesquiterpene
Definition : A C15 terpene.
 terpene
Definition : A hydrocarbon of biological origin having carbon skeleton formally derived from isoprene [CH22C(CH3)CH2CH2].
 ammonia
Mass : 17.03056
Formula : H3N
16134
huperzine A is a Conjugate Base of
huperzine A(1+)
Mass : 243.329
Formula : C15H19N2O
178022
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