CHEBI:229225 - bexagliflozin

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ChEBI Name bexagliflozin
ChEBI ID CHEBI:229225
Definition A C-glycosyl comprising of β-D-glucose in which the anomeric hydroxy group is replaced by a 4-chloro-3-({4-[2-(cyclopropyloxy)ethoxy]phenyl}methyl)phenyl group. It is a sodium-glucose co-transporter 2 (SGLT2) inhibitor indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C24H29ClO7
Net Charge 0
Average Mass 464.940
Monoisotopic Mass 464.16018
InChI InChI=1S/C24H29ClO7/c25-19-8-3-15(24-23(29)22(28)21(27)20(13-26)32-24)12-16(19)11-14-1-4-17(5-2-14)30-9-10-31-18-6-7-18/h1-5,8,12,18,20-24,26-29H,6-7,9-11,13H2/t20-,21-,22+,23-,24+/m1/s1
InChIKey BTCRKOKVYTVOLU-SJSRKZJXSA-N
SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)C1=CC=C(Cl)C(CC2=CC=C(OCCOC3CC3)C=C2)=C1
Roles Classification
Biological Role(s): sodium-glucose transport protein subtype 2 inhibitor
Any inhibitor that interferes with the action of sodium-glucose transport protein subtype 2.
Application(s): hypoglycemic agent
A drug which lowers the blood glucose level.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing bexagliflozin (CHEBI:229225) has role antihypertensive agent (CHEBI:35674)
bexagliflozin (CHEBI:229225) has role hypoglycemic agent (CHEBI:35526)
bexagliflozin (CHEBI:229225) has role sodium-glucose transport protein subtype 2 inhibitor (CHEBI:73273)
bexagliflozin (CHEBI:229225) is a C-glycosyl compound (CHEBI:20857)
bexagliflozin (CHEBI:229225) is a aromatic ether (CHEBI:35618)
bexagliflozin (CHEBI:229225) is a cyclopropanes (CHEBI:51454)
bexagliflozin (CHEBI:229225) is a diether (CHEBI:46786)
bexagliflozin (CHEBI:229225) is a monochlorobenzenes (CHEBI:83403)
IUPAC Name
(1S)-1,5-anhydro-1-(4-chloro-3-{4-[2-(cyclopropyloxy)ethoxy]benzyl}phenyl)-D-glucitol
INNs Sources
bexagliflozin WHO MedNet
bexagliflozina WHO MedNet
bexagliflozine WHO MedNet
bexagliflozinum WHO MedNet
Synonyms Sources
(1S)-1,5-anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-D-glucitol ChEBI
(2S,3R,4R,5S,6R)-2-(4-chloro-3-{4-[2-(cyclopropyloxy)ethoxy]benzyl}phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol IUPAC
(2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[2-(cyclopropyloxy)ethoxy]phenyl}methyl)phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol IUPAC
EGT 1442 ChEBI
EGT-1442 DrugBank
EGT0001442 DrugBank
EGT1442 DrugBank
THR 1442 ChEBI
THR-1442 DrugBank
THR1442 DrugBank
Brand Name Source
Brenzavvy KEGG DRUG
Manual Xrefs Databases
Bexagliflozin Wikipedia
D10865 KEGG DRUG
DB12236 DrugBank
View more database links
Registry Number Type Source
1118567-05-7 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
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Last Modified
16 April 2024