CHEBI:6343 - labetalol

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name labetalol
ChEBI ID CHEBI:6343
Definition A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
Stars This entity has been manually annotated by the ChEBI Team.
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C19H24N2O3
Net Charge 0
Average Mass 328.412
Monoisotopic Mass 328.17869
Roles Classification
Biological Role(s): sympatholytic agent
Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
Application(s): antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
sympatholytic agent
Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing labetalol (CHEBI:6343) has part (R,R)-labetalol (CHEBI:94471)
labetalol (CHEBI:6343) has part (R,S)-labetolol (CHEBI:167640)
labetalol (CHEBI:6343) has part (S,R)-labetolol (CHEBI:167641)
labetalol (CHEBI:6343) has part (S,S)-labetalol (CHEBI:167639)
labetalol (CHEBI:6343) has role α-adrenergic antagonist (CHEBI:37890)
labetalol (CHEBI:6343) has role β-adrenergic antagonist (CHEBI:35530)
labetalol (CHEBI:6343) has role antihypertensive agent (CHEBI:35674)
labetalol (CHEBI:6343) has role sympatholytic agent (CHEBI:66991)
labetalol (CHEBI:6343) is a diastereoisomeric mixture (CHEBI:60915)
IUPAC Name
2-hydroxy-5-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl}benzamide
INNs Sources
labétalol ChEBI
labetalol ChEBI
labetalolum ChEBI
Synonyms Sources
3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol ChemIDplus
5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide ChemIDplus
kabetalol
Note: (2017-06-19) Misnomer used in PMID:28166217.
ChEBI
Labetalol KEGG COMPOUND
Manual Xrefs Databases
1531 DrugCentral
C07063 KEGG COMPOUND
D08106 KEGG DRUG
DB00598 DrugBank
DE2032642 Patent
HMDB0014736 HMDB
Labetalol Wikipedia
LSM-1282 LINCS
US4012444 Patent
View more database links
Registry Numbers Types Sources
2948416 Beilstein Registry Number Beilstein
2948416 Reaxys Registry Number Reaxys
36894-69-6 CAS Registry Number ChemIDplus
36894-69-6 CAS Registry Number NIST Chemistry WebBook
Citations Waiting for Citations Types Sources
1447344 PubMed citation Europe PMC
16795017 PubMed citation Europe PMC
21908132 PubMed citation Europe PMC
22300487 PubMed citation Europe PMC
22528277 PubMed citation Europe PMC
23055089 PubMed citation Europe PMC
28166217 PubMed citation Europe PMC
31643185 PubMed citation Europe PMC
32709242 PubMed citation Europe PMC
33210850 PubMed citation Europe PMC
33424327 PubMed citation Europe PMC
33638710 PubMed citation Europe PMC
33893609 PubMed citation Europe PMC
34217067 PubMed citation Europe PMC
35075411 PubMed citation Europe PMC
7295463 PubMed citation Europe PMC
Last Modified
27 April 2022