CHEBI:229526 - sparsentan

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ChEBI Name sparsentan
ChEBI ID CHEBI:229526
Definition A biphenyl that is 1,1'-biphenyl substituted by (4,5-dimethyl-1,2-oxazol-3-yl)aminosulfonyl, ethoxymethyl, and (2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl groups at positions 2, 2' and 4', respectively. It is a dual antagonist of endothelin and angiotensin II receptors approved for the reduction of proteinuria in adults with primary immunoglobulin A nephropathy at risk of rapid disease progression.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C32H40N4O5S
Net Charge 0
Average Mass 592.760
Monoisotopic Mass 592.27194
InChI InChI=1S/C32H40N4O5S/c1-5-7-14-29-33-32(17-10-11-18-32)31(37)36(29)20-24-15-16-26(25(19-24)21-40-6-2)27-12-8-9-13-28(27)42(38,39)35-30-22(3)23(4)41-34-30/h8-9,12-13,15-16,19H,5-7,10-11,14,17-18,20-21H2,1-4H3,(H,34,35)
InChIKey WRFHGDPIDHPWIQ-UHFFFAOYSA-N
SMILES CCCCC1=NC2(CCCC2)C(=O)N1CC1=CC(COCC)=C(C=C1)C1=C(C=CC=C1)S(=O)(=O)NC1=NOC(C)=C1C
Roles Classification
Biological Role(s): angiotensin receptor antagonist
A hormone antagonist that blocks angiotensin receptors.
endothelin A receptor antagonist
A endothelin receptor antagonist is a drug which selectively blocks endothelin A receptors.
Application(s): angiotensin receptor antagonist
A hormone antagonist that blocks angiotensin receptors.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
endothelin A receptor antagonist
A endothelin receptor antagonist is a drug which selectively blocks endothelin A receptors.
nephroprotective agent
Any protective agent that is able to prevent damage to the kidney.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing sparsentan (CHEBI:229526) has role angiotensin receptor antagonist (CHEBI:61016)
sparsentan (CHEBI:229526) has role antihypertensive agent (CHEBI:35674)
sparsentan (CHEBI:229526) has role endothelin A receptor antagonist (CHEBI:51452)
sparsentan (CHEBI:229526) has role nephroprotective agent (CHEBI:76595)
sparsentan (CHEBI:229526) is a azaspiro compound (CHEBI:35624)
sparsentan (CHEBI:229526) is a benzyl ether (CHEBI:59859)
sparsentan (CHEBI:229526) is a biphenyls (CHEBI:22888)
sparsentan (CHEBI:229526) is a isoxazoles (CHEBI:55373)
sparsentan (CHEBI:229526) is a sulfonamide (CHEBI:35358)
IUPAC Name
4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)-2'-(ethoxymethyl)[biphenyl]-2-sulfonamide
INNs Sources
esparsentán WHO MedNet
sparsentan WHO MedNet
sparsentan WHO MedNet
sparsentanum WHO MedNet
Synonyms Sources
2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)benzenesulfonamide ChEBI
PS 433540 ChEBI
PS-433540 DrugBank
PS433540 DrugBank
RE-021 DrugBank
Brand Name Source
Filspari KEGG DRUG
Manual Xrefs Databases
D11776 KEGG DRUG
DB12548 DrugBank
Sparsentan Wikipedia
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Last Modified
16 April 2024