CHEBI:5556 - guanadrel sulfate

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ChEBI Name guanadrel sulfate
ChEBI ID CHEBI:5556
Definition An organic sulfate salt resulting from the reaction of 2 eq. guanadrel with 1 eq. sulfuric acid. A postganglionic adrenergic blocking agent formerly used for the management of hypertension, it has been largely superseded by other drugs less likely to cause orthostatic hypotension (dizzy spells on standing up or stretching).
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C20H40N6O8S
Net Charge 0
Average Mass 524.63200
Monoisotopic Mass 524.26283
InChI InChI=1S/2C10H19N3O2.H2O4S/c2*11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10;1-5(2,3)4/h2*8H,1-7H2,(H4,11,12,13);(H2,1,2,3,4)
InChIKey RTEVGQJRTFFMLL-UHFFFAOYSA-N
SMILES OS(O)(=O)=O.NC(=N)NCC1COC2(CCCCC2)O1.NC(=N)NCC1COC2(CCCCC2)O1
Roles Classification
Biological Role(s): adrenergic antagonist
An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.
Application(s): adrenergic antagonist
An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
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ChEBI Ontology
Outgoing guanadrel sulfate (CHEBI:5556) has part guanadrel(1+) (CHEBI:72602)
guanadrel sulfate (CHEBI:5556) has role adrenergic antagonist (CHEBI:37887)
guanadrel sulfate (CHEBI:5556) has role antihypertensive agent (CHEBI:35674)
guanadrel sulfate (CHEBI:5556) is a organic sulfate salt (CHEBI:51337)
IUPAC Name
1-(1,4-dioxaspiro[4.5]dec-2-ylmethyl)guanidine sulfate
Synonyms Sources
bis{amino[(1,4-dioxaspiro[4.5]dec-2-ylmethyl)amino]methaniminium} sulfate IUPAC
CL 1388R ChemIDplus
CL-1388R ChemIDplus
U 28288D ChemIDplus
U-28,288D ChemIDplus
Brand Names Sources
Anarel ChEBI
Hylorel KEGG DRUG
Manual Xrefs Databases
D00607 KEGG DRUG
DBSALT000889 DrugBank
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Registry Numbers Types Sources
13410559 Reaxys Registry Number Reaxys
22195-34-2 CAS Registry Number KEGG DRUG
22195-34-2 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
2000792 PubMed citation Europe PMC
4984036 PubMed citation Europe PMC
4984037 PubMed citation Europe PMC
6351026 PubMed citation Europe PMC
6621504 PubMed citation Europe PMC
6762533 PubMed citation Europe PMC
Last Modified
25 May 2022