guanethidine (CHEBI:5557)

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ChEBI Name	guanethidine

ChEBI ID	CHEBI:5557

Definition	A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C10H22N4

Net Charge

Average Mass

198.30850

Monoisotopic Mass

198.18445

InChI

InChI=1S/C10H22N4/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14/h1-9H2,(H4,11,12,13)

InChIKey

ACGDKVXYNVEAGU-UHFFFAOYSA-N

SMILES

NC(=N)NCCN1CCCCCCC1

Roles Classification
Biological Role(s):	adrenergic antagonist An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. sympatholytic agent Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).

Application(s):	antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. adrenergic antagonist An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. sympatholytic agent Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS).

ChEBI Ontology
Outgoing	guanethidine (CHEBI:5557) has functional parent guanidine (CHEBI:42820) guanethidine (CHEBI:5557) has parent hydride azocane (CHEBI:38792) guanethidine (CHEBI:5557) has role adrenergic antagonist (CHEBI:37887) guanethidine (CHEBI:5557) has role antihypertensive agent (CHEBI:35674) guanethidine (CHEBI:5557) has role sympatholytic agent (CHEBI:66991) guanethidine (CHEBI:5557) is a azocanes (CHEBI:38791) guanethidine (CHEBI:5557) is a guanidines (CHEBI:24436)

Incoming	guanethidine monosulfate (CHEBI:51016) has part guanethidine (CHEBI:5557)

IUPAC Name

1-(2-azocan-1-ylethyl)guanidine

Synonyms	Sources
(2-(Octahydro-1-azocinyl)ethyl)guanidine	ChemIDplus
2-(1'-Azacyclooctyl)ethylguanidine	ChemIDplus
2-(1-N,N-Heptamethyleneimino)ethylguanidine	ChemIDplus
Azocine, 1-(2-guanidinoethyl)octahydro-	ChemIDplus
Guanethidine	KEGG COMPOUND
Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-	ChemIDplus
Heptamethylenimine, 1-(2-guanidinoethyl)-	ChemIDplus
N-(2-Perhydroazocin-1-ylethyl)guanidine	ChemIDplus

Last Modified

22 February 2017