CHEBI:64200 - carmoxirole

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ChEBI Name carmoxirole
ChEBI ID CHEBI:64200
Definition An indolecarboxylic acid that is indole-5-carboxylic acid bearing an additional 4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl substituent at position 3. Selective, peripherally acting dopamine D2 receptor agonist. Modulates noradrenalin release and sympathetic activation. Displays antihypertensive properties in vivo.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C24H26N2O2
Net Charge 0
Average Mass 374.47540
Monoisotopic Mass 374.19943
InChI InChI=1S/C24H26N2O2/c27-24(28)20-9-10-23-22(16-20)21(17-25-23)8-4-5-13-26-14-11-19(12-15-26)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,25H,4-5,8,12-15H2,(H,27,28)
InChIKey AFSOIHMEOKEZJF-UHFFFAOYSA-N
SMILES OC(=O)c1ccc2[nH]cc(CCCCN3CCC(=CC3)c3ccccc3)c2c1
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): dopamine agonist
A drug that binds to and activates dopamine receptors.
Application(s): antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
dopamine agonist
A drug that binds to and activates dopamine receptors.
platelet aggregation inhibitor
A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
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ChEBI Ontology
Outgoing carmoxirole (CHEBI:64200) has role antihypertensive agent (CHEBI:35674)
carmoxirole (CHEBI:64200) has role dopamine agonist (CHEBI:51065)
carmoxirole (CHEBI:64200) has role platelet aggregation inhibitor (CHEBI:50427)
carmoxirole (CHEBI:64200) is a indolecarboxylic acid (CHEBI:38610)
carmoxirole (CHEBI:64200) is a tertiary amino compound (CHEBI:50996)
carmoxirole (CHEBI:64200) is a tetrahydropyridine (CHEBI:26921)
carmoxirole (CHEBI:64200) is conjugate base of carmoxirole(1+) (CHEBI:64201)
Incoming carmoxirole(1+) (CHEBI:64201) is conjugate acid of carmoxirole (CHEBI:64200)
IUPAC Name
3-[4-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)butyl]-1H-indole-5-carboxylic acid
INNs Sources
carmoxirol ChemIDplus
carmoxirole ChemIDplus
carmoxirolum ChemIDplus
Synonym Source
3-(4-(3,6-Dihydro-4-phenyl-1(2H)-pyridyl)butyl)indole-5-carboxylic acid ChemIDplus
Manual Xrefs Databases
DE3342632 Patent
EP0548635 Patent
LSM-3850 LINCS
US5256673 Patent
View more database links
Registry Numbers Types Sources
5772553 Reaxys Registry Number Reaxys
98323-83-2 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
10099036 PubMed citation Europe PMC
12106810 PubMed citation Europe PMC
1352381 PubMed citation Europe PMC
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1682817 PubMed citation Europe PMC
22051191 PubMed citation Europe PMC
7757314 PubMed citation Europe PMC
7902890 PubMed citation Europe PMC
8097997 PubMed citation Europe PMC
9825185 PubMed citation Europe PMC
Last Modified
25 February 2016