carfenazine (CHEBI:51235)

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ChEBI Name	carfenazine

ChEBI ID	CHEBI:51235

Definition	A member of the class of phenothiazines that is 10H-phenothiazine which carries a propanoyl group at position 2 and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at position N-10. It is an antipsychotic drug that is used for the treatment of chronic schizophrenia.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C24H31N3O2S

Net Charge

Average Mass

411.56138

Monoisotopic Mass

411.19805

InChI

InChI=1S/C24H31N3O2S/c1-2-22(29)19-8-9-24-21(18-19)27(20-6-3-4-7-23(20)30-24)11-5-10-25-12-14-26(15-13-25)16-17-28/h3-4,6-9,18,28H,2,5,10-17H2,1H3

InChIKey

XZSMZRXAEFNJCU-UHFFFAOYSA-N

SMILES

CCC(=O)C1=CC2=C(SC3=C(C=CC=C3)N2CCCN2CCN(CCO)CC2)C=C1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.

Application(s):	dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. phenothiazine antipsychotic drug

ChEBI Ontology
Outgoing	carfenazine (CHEBI:51235) has role antiemetic (CHEBI:50919) carfenazine (CHEBI:51235) has role dopaminergic antagonist (CHEBI:48561) carfenazine (CHEBI:51235) has role phenothiazine antipsychotic drug (CHEBI:37930) carfenazine (CHEBI:51235) is a N-(2-hydroxyethyl)piperazine (CHEBI:46851) carfenazine (CHEBI:51235) is a N-alkylpiperazine (CHEBI:46845) carfenazine (CHEBI:51235) is a aromatic ketone (CHEBI:76224) carfenazine (CHEBI:51235) is a phenothiazines (CHEBI:38093)

Incoming	carphenazine maleate (CHEBI:51241) has part carfenazine (CHEBI:51235)

IUPAC Name

1-(10-{3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl}-10H-phenothiazin-2-yl)propan-1-one

Synonyms	Sources
1-(10-(3-(4-(2-hydroxyethyl)-1-piperazinyl)propyl)phenothiazin-2-yl)-1-propanone	ChemIDplus
carphenazine	ChemIDplus

Last Modified

19 March 2021