InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1 |
GRTOGORTSDXSFK-XJTZBENFSA-N |
[H][C@]12CN3CCC4=C(NC5=C4C=CC=C5)[C@]3([H])C[C@]1([H])C(=CO[C@H]2C)C(=O)OC |
|
Uncaria elliptica
(IPNI:768231-1)
|
Found in
bark
(BTO:0001301).
See:
Diyabalanage, T.K.K., Kumarihamy, B.M.M., Wannigama, G.P., Jayasinghe, L., Merlini, L. and Scaglioni, L. (1997) Alkaloids of Uncaria elliptica. Phytochemistry, 45(8), 1731-1732.
|
Melodinus khasianus
(IPNI:80218-1)
|
See:
PubMed
|
Catharanthus lanceus
(NCBI:txid1750993)
|
See:
PubMed
|
Vinca major
(NCBI:txid185238)
|
See:
Cheng, G.G., Zhao, Y.L., Zhang, Y., Lunga, P.K., Hu, D.B., Li, Y., Gu, J., Song, C.W., Sun, W.B., Liu, Y.P. and Luo, X.D. (2014) Indole alkaloids from cultivated Vinca major. Tetrahedron, 70(45), 8723-8729.
|
Rauvolfia verticillata
(NCBI:txid329875)
|
Found in
bark
(BTO:0001301).
Isolated from root bark
See:
Kan, N.G. and Nikolaeva, L.A. (1991) Alkaloids of Rauwolfia species growing in Vietnam. Chem. Nat. Compd., 27(6), 718-720.
|
Catharanthus roseus
(NCBI:txid4058)
|
Found in
root
(BTO:0001188).
See:
PubMed
|
Catharanthus roseus
(NCBI:txid4058)
|
Found in
aerial part
(BTO:0001658).
See:
PubMed
|
Rauwolfia oreogiton
(NCBI:txid4059)
|
Found in
bark
(BTO:0001301).
Isolated from root bark
See:
PubMed
|
Rauvolfia serpentina
(NCBI:txid4060)
|
Found in
root
(BTO:0001188).
See:
Klohs, M.W., Draper, M.D., Keller, F., Malesh, W. and Petracek, F.J. (1954) Alkaloids of Rauwolfia serpentina benth. II. The isolation of naturally occurring py-tetrahydroserpentine (ajmalicine) and a contribution toward its structure. J. Am. Chem. Soc., 76(5), 1332-1334.
|
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via alkaloid )
|
|
antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
vasodilator agent
A drug used to cause dilation of the blood vessels.
|
|
View more via ChEBI Ontology
methyl (19α)-19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate
|
(19α)-16,17-didehydro-19-methyl-oxayohimban-16-carboxylic acid methyl ester
|
ChEBI
|
ajmalicin
|
ChemIDplus
|
ajmalicine
|
KEGG COMPOUND
|
δ-yohimbine
|
ChemIDplus
|
methyl (4S,4aR,13bS,14aS)-4-methyl-4a,5,7,8,13,13b,14,14a-octahydro-4H-indolo[2,3-a]pyrano[3,4-g]quinolizine-1-carboxylate
|
ChEBI
|
raubasine
|
ChemIDplus
|
Circolene
|
ChemIDplus
|
Cristanyl
|
ChEBI
|
Duxil
|
ChemIDplus
|
Lamuran
|
KEGG DRUG
|
Sarpan
|
ChemIDplus
|
483-04-5
|
CAS Registry Number
|
KEGG COMPOUND
|
483-04-5
|
CAS Registry Number
|
ChemIDplus
|
483-04-5
|
CAS Registry Number
|
NIST Chemistry WebBook
|
97268
|
Reaxys Registry Number
|
Reaxys
|
15930738
|
PubMed citation
|
Europe PMC
|
19151732
|
PubMed citation
|
Europe PMC
|
22331368
|
PubMed citation
|
Europe PMC
|
22332772
|
PubMed citation
|
Europe PMC
|
24237015
|
PubMed citation
|
Europe PMC
|
25555909
|
PubMed citation
|
Europe PMC
|
26983347
|
PubMed citation
|
Europe PMC
|
27584856
|
PubMed citation
|
Europe PMC
|
4387608
|
PubMed citation
|
Europe PMC
|
6091834
|
PubMed citation
|
Europe PMC
|
6128043
|
PubMed citation
|
Europe PMC
|
|