CHEBI:89455 - 18-hydroxycortisol

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name 18-hydroxycortisol
ChEBI ID CHEBI:89455
Definition A 18-hydroxy steroid that is cortisol carrying a hydroxy group at position 18. Its urinary excretion is increased in patients with aldosterone-producing adenoma.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C21H30O6
Net Charge 0
Average Mass 378.465
Monoisotopic Mass 378.20424
InChI InChI=1S/C21H30O6/c1-19-6-4-13(24)8-12(19)2-3-14-15-5-7-21(27,17(26)10-22)20(15,11-23)9-16(25)18(14)19/h8,14-16,18,22-23,25,27H,2-7,9-11H2,1H3/t14-,15-,16-,18+,19-,20+,21-/m0/s1
InChIKey HESFZGWRDUVOMS-UKSDXMLSSA-N
SMILES [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(CO)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Metabolite of Species Details
Homo sapiens (NCBI:txid9606) Found in blood (UBERON:0000178). See: PubMed
Homo sapiens (NCBI:txid9606) Found in urine (BTO:0001419). See: PubMed
Roles Classification
Biological Role(s): human urinary metabolite
Any metabolite (endogenous or exogenous) found in human urine samples.
hormone
Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
(via steroid hormone )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing 18-hydroxycortisol (CHEBI:89455) has functional parent cortisol (CHEBI:17650)
18-hydroxycortisol (CHEBI:89455) has parent hydride pregnane (CHEBI:8386)
18-hydroxycortisol (CHEBI:89455) has role human urinary metabolite (CHEBI:84087)
18-hydroxycortisol (CHEBI:89455) is a 11β-hydroxy steroid (CHEBI:35346)
18-hydroxycortisol (CHEBI:89455) is a 17α-hydroxy-C21-steroid (CHEBI:138141)
18-hydroxycortisol (CHEBI:89455) is a 18-hydroxy steroid (CHEBI:36855)
18-hydroxycortisol (CHEBI:89455) is a 20-oxo steroid (CHEBI:36885)
18-hydroxycortisol (CHEBI:89455) is a 21-hydroxy steroid (CHEBI:35344)
18-hydroxycortisol (CHEBI:89455) is a 3-oxo-Δ4 steroid (CHEBI:47909)
18-hydroxycortisol (CHEBI:89455) is a glucocorticoid (CHEBI:24261)
18-hydroxycortisol (CHEBI:89455) is a primary α-hydroxy ketone (CHEBI:139590)
18-hydroxycortisol (CHEBI:89455) is a tertiary α-hydroxy ketone (CHEBI:139592)
IUPAC Name
11β,17,18,21-tetrahydroxypregn-4-ene-3,20-dione
Synonyms Sources
(11β)-11,17,18,21-tetrahydroxypregn-4-ene-3,20-dione ChEBI
(11β,17α)-11,17,18,21-tetrahydroxypregn-4-ene-3,20-dione ChEBI
18-hydroxycortisol UniProt
4-pregnene-11β,17,18,21-tetrol-3,20-dione ChEBI
Manual Xrefs Databases
18-Hydroxycortisol Wikipedia
FDB022033 FooDB
HMDB0000418 HMDB
LMST02030295 LIPID MAPS
View more database links
Registry Number Type Source
86002-90-6 CAS Registry Number ChEBI
Citations Waiting for Citations Types Sources
10778083 PubMed citation Europe PMC
11566957 PubMed citation Europe PMC
12429142 PubMed citation Europe PMC
15062555 PubMed citation Europe PMC
15356073 PubMed citation Europe PMC
1560187 PubMed citation Europe PMC
1567095 PubMed citation Europe PMC
15941931 PubMed citation Europe PMC
16149517 PubMed citation Europe PMC
1879399 PubMed citation Europe PMC
20963880 PubMed citation Europe PMC
22238407 PubMed citation Europe PMC
23847032 PubMed citation Europe PMC
2811370 PubMed citation Europe PMC
28904009 PubMed citation Europe PMC
3002670 PubMed citation Europe PMC
34871919 PubMed citation Europe PMC
35778951 PubMed citation Europe PMC
3995762 PubMed citation Europe PMC
8001289 PubMed citation Europe PMC
8038908 PubMed citation Europe PMC
8049145 PubMed citation Europe PMC
8516344 PubMed citation Europe PMC
8753282 PubMed citation Europe PMC
9090795 PubMed citation Europe PMC
9279964 PubMed citation Europe PMC
9814482 PubMed citation Europe PMC
9831489 PubMed citation Europe PMC
Last Modified
30 March 2023