telatinib (CHEBI:231351)

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ChEBI Name	telatinib

ChEBI ID	CHEBI:231351

Definition	A member of the class of furopyridazines that is furo[2,3-d]pyridazine substituted by (4-chlorophenyl)amino and [2-(methylcarbamoyl)pyridin-4-yl]methoxy groups at positions 4 and 7, respectively. It is a potent inhibitor of VEGFR2/3, c-Kit and PDGFRα.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Delphine Zhou

Supplier Information

Download	Molfile XML SDF

Formula

C20H16ClN5O3

Net Charge

Average Mass

409.830

Monoisotopic Mass

409.09417

InChI

InChI=1S/C20H16ClN5O3/c1-22-19(27)16-10-12(6-8-23-16)11-29-20-17-15(7-9-28-17)18(25-26-20)24-14-4-2-13(21)3-5-14/h2-10H,11H2,1H3,(H,22,27)(H,24,25)

InChIKey

QFCXANHHBCGMAS-UHFFFAOYSA-N

SMILES

CNC(=O)C1=NC=CC(COC2=NN=C(NC3=CC=C(Cl)C=C3)C3=C2OC=C3)=C1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	vascular endothelial growth factor receptor antagonist An antagonist at the vascular endothelial growth factor receptor. EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1). apoptosis inducer Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.

Application(s):	antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.

ChEBI Ontology
Outgoing	telatinib (CHEBI:231351) has role angiogenesis inhibitor (CHEBI:48422) telatinib (CHEBI:231351) has role antineoplastic agent (CHEBI:35610) telatinib (CHEBI:231351) has role apoptosis inducer (CHEBI:68495) telatinib (CHEBI:231351) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434) telatinib (CHEBI:231351) has role vascular endothelial growth factor receptor antagonist (CHEBI:65207) telatinib (CHEBI:231351) is a anilines (CHEBI:22562) telatinib (CHEBI:231351) is a aromatic ether (CHEBI:35618) telatinib (CHEBI:231351) is a furopyridazine (CHEBI:231410) telatinib (CHEBI:231351) is a monochlorobenzenes (CHEBI:83403) telatinib (CHEBI:231351) is a pyridinecarboxamide (CHEBI:25529)

IUPAC Name

4-({[4-(4-chloroanilino)furo[2,3-d]pyridazin-7-yl]oxy}methyl)-N-methylpyridine-2-carboxamide

Synonyms	Sources
4-(((4-((4-chlorophenyl)amino)furo[2,3-d]pyridazin-7-yl)oxy)methyl)-N-methylpicolinamide	ChEBI
4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-2-pyridinecarboxamide	ChEBI
BAY 57-9352	SUBMITTER
BAY-57-9352	ChEBI
BAY-579352	ChEBI

Registry Number	Type	Source
332012-40-5	CAS Registry Number	SUBMITTER

Last Modified

10 May 2024