CHEBI:71245 - asenapine maleate

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ChEBI Name asenapine maleate
ChEBI ID CHEBI:71245
Definition A racemate consisting of equal amounts of (R,R)- and (S,S)-asenapine maleate. Used for the acute treatment of schizophrenia and acute treatment of manic or mixed episodes associated with bipolar I disorder with or without psychotic features.
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Biological Role(s): alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
Application(s): alpha-adrenergic antagonist
An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
psychotropic drug
A loosely defined grouping of drugs that have effects on psychological function.
second generation antipsychotic
Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
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ChEBI Ontology
Outgoing asenapine maleate (CHEBI:71245) has part (R,R)-asenapine maleate (CHEBI:71246)
asenapine maleate (CHEBI:71245) has part (S,S)-asenapine maleate (CHEBI:71248)
asenapine maleate (CHEBI:71245) has part asenapine(1+) (CHEBI:71249)
asenapine maleate (CHEBI:71245) has role α-adrenergic antagonist (CHEBI:37890)
asenapine maleate (CHEBI:71245) has role β-adrenergic antagonist (CHEBI:35530)
asenapine maleate (CHEBI:71245) has role dopaminergic antagonist (CHEBI:48561)
asenapine maleate (CHEBI:71245) has role psychotropic drug (CHEBI:35471)
asenapine maleate (CHEBI:71245) has role second generation antipsychotic (CHEBI:65191)
asenapine maleate (CHEBI:71245) has role serotonergic antagonist (CHEBI:48279)
asenapine maleate (CHEBI:71245) is a racemate (CHEBI:60911)
IUPAC Names
rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-2-ium (2Z)-3-prop-2-enoate
rac-(3aR,12bR)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-but-2-enedioate
Synonyms Sources
(±)-asenapine maleate ChEBI
(3aRS,12bRS)-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo(2,3:6,7)oxepino(4,5-c)pyrrole (2Z)-2-butenedioate ChemIDplus
(3aRS,12bRS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrol-2-ium (2Z)-3-prop-2-enoate ChEBI
(3aRS,12bRS)-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole (2Z)-but-2-enedioate ChEBI
trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole maleate ChemIDplus
Brand Name Source
Saphris KEGG DRUG
Manual Xrefs Databases
Asenapine Wikipedia
D02995 KEGG DRUG
EP1917267 Patent
KR20080005253 Patent
NZ562124 Patent
WO2011159903 Patent
ZA200708493 Patent
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Registry Numbers Types Sources
3647286 Reaxys Registry Number Reaxys
85650-56-2 CAS Registry Number KEGG DRUG
85650-56-2 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
27 November 2012