N-cyclohexyl-4-(imidazo[1,2-a]pyridin-3-yl)-N-methylpyrimidin-2-amine (CHEBI:78508)

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ChEBI Name	N-cyclohexyl-4-(imidazo[1,2-a]pyridin-3-yl)-N-methylpyrimidin-2-amine

ChEBI ID	CHEBI:78508

ChEBI ASCII Name	N-cyclohexyl-4-(imidazo[1,2-a]pyridin-3-yl)-N-methylpyrimidin-2-amine

Definition	An aminopyrimidine that is N-cyclohexyl-N-methylpyrimidin-2-amine in which the pyrimidine ring is substituted at position 4 by an imidazo[1,2-a]pyridin-3-yl group. It is an inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK-4; EC 2.7.11.1).

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	Matthias Ziehm

Supplier Information

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Formula

C18H21N5

Net Charge

Average Mass

307.39280

Monoisotopic Mass

307.17970

InChI

InChI=1S/C18H21N5/c1-22(14-7-3-2-4-8-14)18-19-11-10-15(21-18)16-13-20-17-9-5-6-12-23(16)17/h5-6,9-14H,2-4,7-8H2,1H3

InChIKey

HYNNWLVWJXWXFO-UHFFFAOYSA-N

SMILES

CN(C1CCCCC1)c1nccc(n1)-c1cnc2ccccn12

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.

ChEBI Ontology
Outgoing	N-cyclohexyl-4-(imidazo[1,2-a]pyridin-3-yl)-N-methylpyrimidin-2-amine (CHEBI:78508) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925) N-cyclohexyl-4-(imidazo[1,2-a]pyridin-3-yl)-N-methylpyrimidin-2-amine (CHEBI:78508) is a aminopyrimidine (CHEBI:38338) N-cyclohexyl-4-(imidazo[1,2-a]pyridin-3-yl)-N-methylpyrimidin-2-amine (CHEBI:78508) is a imidazopyridine (CHEBI:46908)

IUPAC Name

N-cyclohexyl-4-(imidazo[1,2-a]pyridin-3-yl)-N-methylpyrimidin-2-amine

Registry Number	Type	Source
26145508	Reaxys Registry Number	Reaxys

Last Modified

06 July 2016

General Comment
2014-05-23	See G. M. Buckley et al., Bioorg. Med. Chem. Lett., 2008, 18(11), 3291-3295 and Z. Whang et al., Curr. Top. Med. Chem., 2009, 9(8), 724-737.