CHEBI:229234 - ritlecitinib tosylate

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ChEBI Name ritlecitinib tosylate
ChEBI ID CHEBI:229234
Definition An organosulfonate salt obtained by combining equimolar amounts of ritlecitinib and 4-toluenesulfonic acid. It is a kinase inhibitor, developed by Pfizer for the treatment of severe alopecia areata in adults and adolescents 12 years and older.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C15H19N5O.C7H8O3S
Net Charge 0
Average Mass 457.550
Monoisotopic Mass 457.17838
InChI InChI=1S/C15H19N5O.C7H8O3S/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15;1-6-2-4-7(5-3-6)11(8,9)10/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19);2-5H,1H3,(H,8,9,10)/t10-,11+;/m0./s1
InChIKey YOZLVAFWYLSRRN-VZXYPILPSA-N
SMILES CC1=CC=C(C=C1)S(O)(=O)=O.C[C@H]1CC[C@H](CN1C(=O)C=C)NC1=C2C=CNC2=NC=N1
Roles Classification
Biological Role(s): EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2).
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
Application(s): dermatologic drug
A drug used to treat or prevent skin disorders or for the routine care of skin.
anti-inflammatory drug
A substance that reduces or suppresses inflammation.
immunosuppressive agent
An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
antirheumatic drug
A drug used to treat rheumatoid arthritis.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing ritlecitinib tosylate (CHEBI:229234) has part ritlecitinib(1+) (CHEBI:229235)
ritlecitinib tosylate (CHEBI:229234) has role anti-inflammatory drug (CHEBI:35472)
ritlecitinib tosylate (CHEBI:229234) has role antirheumatic drug (CHEBI:35842)
ritlecitinib tosylate (CHEBI:229234) has role dermatologic drug (CHEBI:50177)
ritlecitinib tosylate (CHEBI:229234) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617)
ritlecitinib tosylate (CHEBI:229234) has role immunosuppressive agent (CHEBI:35705)
ritlecitinib tosylate (CHEBI:229234) is a organosulfonate salt (CHEBI:64382)
IUPAC Name
1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one 4-methylbenzenesulfonate (1:1)
Synonyms Sources
1-{(2S,5R)-2-methyl-5-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}prop-2-en-1-one 4 methylbenzene-1-sulfonic acid ChEBI
4-methylbenzene-1-sulfonic acid—1-{(2S,5R)-2-methyl-5-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}prop-2-en-1-one (1/1) IUPAC
PF-06651600 tosylate DrugBank
ritlecitinib tosilate KEGG DRUG
Brand Name Source
Litfulo KEGG DRUG
Manual Xrefs Databases
D11970 KEGG DRUG
DBSALT003482 DrugBank
View more database links
Registry Number Type Source
2192215-81-7 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
37556041 PubMed citation Europe PMC
37703124 PubMed citation Europe PMC
37983117 PubMed citation Europe PMC
38051245 PubMed citation Europe PMC
38051803 PubMed citation Europe PMC
Last Modified
17 April 2024