LY-165163 (CHEBI:92250)

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ChEBI Name	LY-165163

ChEBI ID	CHEBI:92250

Definition	A N-arylpiperazine that is piperazine substituted by 2-(4-aminophenyl)ethyl and 3-(trifluoromethyl)phenyl groups at positions 1 and 4, respectively. It is a selective 5-HT_1A serotonin receptor agonist and 5-HT_1D serotonin receptor antagonist.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C19H22F3N3

Net Charge

Average Mass

349.401

Monoisotopic Mass

349.17658

InChI

InChI=1S/C19H22F3N3/c20-19(21,22)16-2-1-3-18(14-16)25-12-10-24(11-13-25)9-8-15-4-6-17(23)7-5-15/h1-7,14H,8-13,23H2

InChIKey

GAAKALASJNGQKD-UHFFFAOYSA-N

SMILES

NC1=CC=C(CCN2CCN(CC2)C2=CC=CC(=C2)C(F)(F)F)C=C1

Roles Classification
Chemical Role(s):	Bronsted base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). (via organic amino compound )

Biological Role(s):	serotonergic agonist An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.

Application(s):	serotonergic agonist An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders. geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.

ChEBI Ontology
Outgoing	LY-165163 (CHEBI:92250) has functional parent 1-(3-(trifluoromethyl)phenyl)piperazine (CHEBI:83536) LY-165163 (CHEBI:92250) has role geroprotector (CHEBI:176497) LY-165163 (CHEBI:92250) has role serotonergic agonist (CHEBI:35941) LY-165163 (CHEBI:92250) is a (trifluoromethyl)benzenes (CHEBI:83565) LY-165163 (CHEBI:92250) is a N-alkylpiperazine (CHEBI:46845) LY-165163 (CHEBI:92250) is a N-arylpiperazine (CHEBI:46848) LY-165163 (CHEBI:92250) is a primary arylamine (CHEBI:50471) LY-165163 (CHEBI:92250) is a substituted aniline (CHEBI:48975)

IUPAC Name

4-(2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethyl)aniline

Synonyms	Sources
1-(2-(4-aminophenyl)ethyl)-4-(3-trifluoromethylphenyl)piperazine	ChemIDplus
1-(m-trifluoromethylphenyl)-4-(p-aminophenylethyl)piperazine	ChEBI
4-(2-(4-(3-(trifluoromethyl)phenyl)-1-piperazinyl)ethyl)-benzenamine	ChEBI
LY 165,163	ChEBI
LY 165163	ChemIDplus
LY-165,163	ChEBI
PAPP	ChemIDplus

Registry Number	Type	Source
1814-64-8	CAS Registry Number	ChemIDplus

Last Modified

18 January 2024