CHEBI:67169 - cortistatins

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ChEBI Name cortistatins
ChEBI ID CHEBI:67169
Definition Any member of a class of steroidal alkaloids obtained from the marine sponge Corticium simplex, with a basic skeleton that is (5R,8β)-5,8-epoxy-9,19-cyclo-9,10-secoandrostane, bearing a dimethylamino substituent at position 3 and an isoquinolin-7-yl or isoquinolin-7-yl-derived substituent at position 17. They selectively inhibit proliferation of human umbilical vein endothelial cells (HUVECs).
Stars This entity has been manually annotated by the ChEBI Team.
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Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): metabolite
Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
(via alkaloid )
Application(s): angiogenesis modulating agent
An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents.
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ChEBI Ontology
Outgoing cortistatins (CHEBI:67169) has role angiogenesis modulating agent (CHEBI:50926)
cortistatins (CHEBI:67169) is a polycyclic ether (CHEBI:36468)
cortistatins (CHEBI:67169) is a steroid alkaloid (CHEBI:26767)
cortistatins (CHEBI:67169) is a tertiary amino compound (CHEBI:50996)
Incoming cortistatin A (CHEBI:67171) is a cortistatins (CHEBI:67169)
cortistatin B (CHEBI:67173) is a cortistatins (CHEBI:67169)
cortistatin C (CHEBI:67174) is a cortistatins (CHEBI:67169)
cortistatin D (CHEBI:67175) is a cortistatins (CHEBI:67169)
cortistatin E (CHEBI:67179) is a cortistatins (CHEBI:67169)
Manual Xref Database
Cortistatins Wikipedia
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Citations Waiting for Citations Types Sources
16522087 PubMed citation Europe PMC
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Last Modified
21 August 2012
General Comment
2012-08-21 For isolation of Cortistatins E, F, G, and H see See Watanabe, Y., Aoki, S., Tanabe, D., Setiawan, A., and Kobayashi, M. Cortistatins E, F, G, and H, four novel steroidal alkaloids from marine sponge Corticum simplex. Tetrahedron, 2007, 63, 4074-4079.