CHEBI:32016 - pirfenidone

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ChEBI Name pirfenidone
ChEBI ID CHEBI:32016
Definition A pyridone that is 2-pyridone substituted at positions 1 and 5 by phenyl and methyl groups respectively. An anti-inflammatory drug used for the treatment of idiopathic pulmonary fibrosis.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C12H11NO
Net Charge 0
Average Mass 185.22180
Monoisotopic Mass 185.08406
InChI InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3
InChIKey ISWRGOKTTBVCFA-UHFFFAOYSA-N
SMILES Cc1ccc(=O)n(c1)-c1ccccc1
Roles Classification
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Application(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
antipyretic
A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
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ChEBI Ontology
Outgoing pirfenidone (CHEBI:32016) has role antipyretic (CHEBI:35493)
pirfenidone (CHEBI:32016) has role non-narcotic analgesic (CHEBI:35481)
pirfenidone (CHEBI:32016) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
pirfenidone (CHEBI:32016) is a pyridone (CHEBI:38183)
IUPAC Name
5-methyl-1-phenylpyridin-2(1H)-one
INNs Sources
pirfenidona ChemIDplus
pirfenidone ChemIDplus
pirfenidone KEGG DRUG
pirfenidonum ChemIDplus
Synonyms Sources
AMR 69 ChemIDplus
AMR-69 ChemIDplus
Pirfenidone Deprecated term KEGG COMPOUND
Brand Name Source
Esbriet KEGG DRUG
Manual Xrefs Databases
4224 DrugCentral
D01583 KEGG DRUG
LSM-4190 LINCS
Pirfenidone Wikipedia
View more database links
Registry Numbers Types Sources
1526549 Reaxys Registry Number Reaxys
1526549 Beilstein Registry Number ChemIDplus
53179-13-8 CAS Registry Number ChemIDplus
53179-13-8 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
25432946 PubMed citation Europe PMC
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Last Modified
22 February 2017