clodronic acid disodium salt (CHEBI:59586)

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ChEBI Name	clodronic acid disodium salt

ChEBI ID	CHEBI:59586

Definition	The disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used (generally as the tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

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Formula

CH2Cl2Na2O6P2

Net Charge

Average Mass

288.85600

Monoisotopic Mass

287.84991

InChI

InChI=1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

InChIKey

HJKBJIYDJLVSAO-UHFFFAOYSA-L

SMILES

[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O

Roles Classification
Application(s):	bone density conservation agent An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.

ChEBI Ontology
Outgoing	clodronic acid disodium salt (CHEBI:59586) has part clondronate(2−) (CHEBI:59585) clodronic acid disodium salt (CHEBI:59586) has role bone density conservation agent (CHEBI:50646) clodronic acid disodium salt (CHEBI:59586) is a one-carbon compound (CHEBI:64708) clodronic acid disodium salt (CHEBI:59586) is a organic sodium salt (CHEBI:38700)

Incoming	disodium clodronate tetrahydrate (CHEBI:59587) has part clodronic acid disodium salt (CHEBI:59586)

IUPAC Name

disodium (dichloromethanediyl)bis[hydrogen (phosphonate)]

Synonyms	Sources
clodronate disodium	KEGG DRUG
clodronate sodium	ChemIDplus
clodronic acid disodium salt	KEGG DRUG
disodium (dichloromethylene)bisphosphonate	ChemIDplus
disodium (dichloromethylene)diphosphonate	ChemIDplus
disodium clodronate	ChemIDplus
disodium dichloromethylene diphosphonate	ChemIDplus
disodium dihydrogen (dichloromethylene)diphosphonate	ChemIDplus
sodium clodronate	ChemIDplus

Last Modified

12 June 2012