IPR003186
Proteasome activator PA28, C-terminal domain
InterPro entry
Short name | PA28_C |
Overlapping homologous superfamilies |
Description
The specificity of the 20S proteasome, which degrades many intracellular proteins, is regulated by protein complexes that bind to one or both ends of the cylindrical proteasome structure. Proteasome activator 28 (PA28), also known as 11S regulator or REG, is one of these complexes. PA28 binds to the 20S proteasome and stimulates peptidase activity in and ATP-independent manner.
This entry represents the C-terminal domain found in the proteasome activator 28 subunits.
References
1. Relative functions of the alpha and beta subunits of the proteasome activator, PA28. Song X, von Kampen J, Slaughter CA, DeMartino GN. J. Biol. Chem. 272, 27994-8000, (1997). View articlePMID: 9346951
2. Properties of the beta subunit of the proteasome activator PA28 (11S REG). Wilk S, Chen WE, Magnusson RP. Arch. Biochem. Biophys. 384, 174-80, (2000). View articlePMID: 11147828
3. Structure of the proteasome activator REGalpha (PA28alpha). Knowlton JR, Johnston SC, Whitby FG, Realini C, Zhang Z, Rechsteiner M, Hill CP. Nature 390, 639-43, (1997). View articlePMID: 9403698
GO terms
biological process
- None
molecular function
- None
cellular component
Contributing Member Database Entry
- Pfam:PF02252