F
IPR013178

Histone acetyltransferase Rtt109/CBP

InterPro entry
Short nameHistone_AcTrfase_Rtt109/CBP
family relationships

Description

Histone acetylation is required in many cellular processes including transcription, DNA repair, and chromatin assembly. This family contains the fungal RTT109 protein, which is required for H3K56 acetylation
[5]
. In Schizosaccharomyces pombe (Fission yeast) loss of RTT109 results in the loss of H3K56 acetylation, both on bulk histone and on chromatin
[4]
. RTT109 and H3K56 acetylation appear to correlate with actively transcribed genes and associate with the elongating form of Pol II in yeast
[4]
. This family also includes p300/CBP acetyltransferase, which has different catalytic properties and cofactor regulation to RTT109
[3]
. CREB-binding protein (CBP) is a transcriptional co-activator that acetylates both histones and non-histone proteins
[6, 7, 8]
. CBP binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes
[1, 2]
.

References

1.A transcriptional switch mediated by cofactor methylation. Xu W, Chen H, Du K, Asahara H, Tini M, Emerson BM, Montminy M, Evans RM. Science 294, 2507-11, (2001). View articlePMID: 11701890

2.SUMO modification negatively modulates the transcriptional activity of CREB-binding protein via the recruitment of Daxx. Kuo HY, Chang CC, Jeng JC, Hu HM, Lin DY, Maul GG, Kwok RP, Shih HM. Proc. Natl. Acad. Sci. U.S.A. 102, 16973-8, (2005). View articlePMID: 16287980

3.Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP. Tang Y, Holbert MA, Wurtele H, Meeth K, Rocha W, Gharib M, Jiang E, Thibault P, Verreault A, Verrault A, Cole PA, Marmorstein R. Nat. Struct. Mol. Biol. 15, 738-45, (2008). View articlePMID: 18568037

4.Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II. Schneider J, Bajwa P, Johnson FC, Bhaumik SR, Shilatifard A. J. Biol. Chem. 281, 37270-4, (2006). View articlePMID: 17046836

5.Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication. Han J, Zhou H, Horazdovsky B, Zhang K, Xu RM, Zhang Z. Science 315, 653-5, (2007). View articlePMID: 17272723

6.p300 forms a stable, template-committed complex with chromatin: role for the bromodomain. Manning ET, Ikehara T, Ito T, Kadonaga JT, Kraus WL. Mol. Cell. Biol. 21, 3876-87, (2001). View articlePMID: 11359896

7.CBP and p300: HATs for different occasions. Kalkhoven E. Biochem. Pharmacol. 68, 1145-55, (2004). View articlePMID: 15313412

8.Acetylation of nuclear receptors in cellular growth and apoptosis. Fu M, Wang C, Zhang X, Pestell RG. Biochem. Pharmacol. 68, 1199-208, (2004). View articlePMID: 15313417

GO terms

Cross References

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.