F
IPR016722

DNA polymerase alpha, subunit B

InterPro entry
Short nameDNA_pol_alpha_bsu
Overlapping
homologous
superfamilies
 

Description

This group represents a DNA polymerase alpha, subunit B, which is essential for DNA replication in higher eukaryotes as it initiates synthesis on both leading and lagging strand single-stranded DNA templates. It consists of a primase heterodimer that synthesises RNA primers, a DNA polymerase that extends them, and a fourth subunit, p68 (also termed B-subunit), which is believed to regulate the whole complex. This domain docks on the SV40 helicase and activates the viral primosome
[1]
.

References

1.Structure of a DNA polymerase alpha-primase domain that docks on the SV40 helicase and activates the viral primosome. Huang H, Weiner BE, Zhang H, Fuller BE, Gao Y, Wile BM, Zhao K, Arnett DR, Chazin WJ, Fanning E. J. Biol. Chem. 285, 17112-22, (2010). PMID: 20234039

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