IPR016722
DNA polymerase alpha, subunit B
InterPro entry
Short name | DNA_pol_alpha_bsu |
Overlapping homologous superfamilies |
Description
This group represents a DNA polymerase alpha, subunit B, which is essential for DNA replication in higher eukaryotes as it initiates synthesis on both leading and lagging strand single-stranded DNA templates. It consists of a primase heterodimer that synthesises RNA primers, a DNA polymerase that extends them, and a fourth subunit, p68 (also termed B-subunit), which is believed to regulate the whole complex. This domain docks on the SV40 helicase and activates the viral primosome
[1].
References
Contributing Member Database Entries
- PANTHER:PTHR23061
- PIRSF:PIRSF018300