F
IPR007523

NDUFAF3/Mth938 domain-containing protein

InterPro entry
Short nameNDUFAF3/AAMDC
Overlapping
homologous
superfamilies
 
family relationships

Description

This entry includes NDUFAF3, an essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I)
[2]
, and the Mth938 domain-containing protein
[3]
. The crystal structure of NDUFAF3 revealed a 3-layer β+α/β/α topology
[1]
.

References

1.X-ray crystal structure of MTH938 from Methanobacterium thermoautotrophicum at 2.2 A resolution reveals a novel tertiary protein fold. Das K, Xiao R, Wahlberg E, Hsu F, Arrowsmith CH, Montelione GT, Arnold E. Proteins 45, 486-8, (2001). View articlePMID: 11746696

2.Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease. Saada A, Vogel RO, Hoefs SJ, van den Brand MA, Wessels HJ, Willems PH, Venselaar H, Shaag A, Barghuti F, Reish O, Shohat M, Huynen MA, Smeitink JA, van den Heuvel LP, Nijtmans LG. Am. J. Hum. Genet. 84, 718-27, (2009). View articlePMID: 19463981

3.LOC66273 isoform 2, a novel protein highly expressed in white adipose tissue, induces adipogenesis in 3T3-L1 cells. Ma X, Ding W, Wang J, Wu G, Zhang H, Yin J, Zhou L, Li D. J. Nutr. 142, 448-55, (2012). View articlePMID: 22279136

Further reading

4. The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains. Walker JE. Q. Rev. Biophys. 25, 253-324, (1992). PMID: 1470679

5. Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I). Schneider D, Pohl T, Walter J, Dorner K, Kohlstadt M, Berger A, Spehr V, Friedrich T. Biochim. Biophys. Acta 1777, 735-9, (2008). View articlePMID: 18394423

6. The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases. Friedrich T, Scheide D. FEBS Lett. 479, 1-5, (2000). View articlePMID: 10940377

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