PF02252

Proteasome activator PA28, C-terminal

Pfam entry
Member databasePfam
Pfam typedomain
Short namePA28_C
Author Bateman A;0000-0002-6982-4660 Mian N;0000-0003-4284-4749
Sequence Ontology0000417

Description

Proteasome activator 28 (PA28), also known as 11s regulator of REG, binds to the 20S proteasome and simulates peptidase activity in an ATP-independent manner. This entry represents a the C-terminal domain found in PA28 subunits, including PA28alpha/beta/gamma (also known as Proteasome activator complex subunit 1-3) [1-4].

References

1. Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins. Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y. Proc Natl Acad Sci U S A 119, e2207200119, (2022). View articlePMID: 35858375

2. Atomic resolution Cryo-EM structure of human proteasome activator PA28γ. Chen DD, Hao J, Shen CH, Deng XM, Yun CH. Int J Biol Macromol 219, 500-507, (2022). View articlePMID: 35932807

3. Structure of the proteasome activator REGalpha (PA28alpha). Knowlton JR, Johnston SC, Whitby FG, Realini C, Zhang Z, Rechsteiner M, Hill CP. Nature 390, 639-43, (1997). View articlePMID: 9403698

4. Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes. Kohda K, Ishibashi T, Shimbara N, Tanaka K, Matsuda Y, Kasahara M. J. Immunol. 160, 4923-35, (1998). View articlePMID: 9590240

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