› 110d

X-ray diffraction
1.9Å resolution

ANTHRACYCLINE-DNA INTERACTIONS AT UNFAVOURABLE BASE BASE-PAIR TRIPLET-BINDING SITES: STRUCTURES OF D(CGGCCG)/DAUNOMYCIN AND D(TGGCCA)/ADRIAMYCIN COMPL

Released:
DOI: 10.2210/pdb110d/pdb
PDB entry 110d coloured by chain, front view.
PDB entry 110d coloured by chain, side view.
PDB entry 110d coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Anthracycline-DNA interactions at unfavourable base-pair triplet-binding sites: structures of d(CGGCCG)/daunomycin and d(TGGCCA)/adriamycin complexes.
Leonard GA, Hambley TW, McAuley-Hecht K, Brown T, Hunter WN
Acta Crystallogr D Biol Crystallogr 49 458-67 (1993)
PMID: 15299505

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113302 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*CP*GP*GP*CP*CP*G)-3') Chain: A
Molecule details ›
Chain: A
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DM1 1 x DM1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P41212
Unit cell:
a: 28.07Å b: 28.07Å c: 53.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 not available not available
Expression system: Not provided

Quick links

Citations

2 review citations

Total biosynthesis: in vitro reconstitution of polyketide and nonribosomal peptide pathways.
Sattely et al. (2008)
1 more

6 mentions without citation

DNA conformations and their sequence preferences.
Svozil et al. (2008)
5 more