› 1y57

X-ray diffraction
1.91Å resolution

Structure of unphosphorylated c-Src in complex with an inhibitor

Released:
DOI: 10.2210/pdb1y57/pdb
PDB entry 1y57 coloured by chain, front view.
PDB entry 1y57 coloured by chain, side view.
PDB entry 1y57 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation.
Cowan-Jacob SW, Fendrich G, Manley PW, Jahnke W, Fabbro D, Liebetanz J, Meyer T
Structure 13 861-71 (2005)
PMID: 15939018

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146379 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proto-oncogene tyrosine-protein kinase Src Chain: A
Molecule details ›
Chain: A
Length: 452 amino acids
Theoretical weight: 51.63 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P12931 (Residues: 86-536; Coverage: 84%)
Gene names: SRC, SRC1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 5 x SO4
Ligand MPZ 1 x MPZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P41212
Unit cell:
a: 106.212Å b: 106.212Å c: 123.731Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.188 0.213
Expression system: Spodoptera frugiperda

Quick links

Citations

27 review citations

Src kinases as therapeutic targets for cancer.
Kim et al. (2009)
26 more

100 mentions without citation

Structure and dynamic regulation of Src-family kinases.
Engen et al. (2008)
99 more