› 1a38

X-ray diffraction
3.35Å resolution

14-3-3 PROTEIN ZETA BOUND TO R18 PEPTIDE

Released:
DOI: 10.2210/pdb1a38/pdb
PDB entry 1a38 coloured by chain, front view.
PDB entry 1a38 coloured by chain, side view.
PDB entry 1a38 coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
Petosa C, Masters SC, Bankston LA, Pohl J, Wang B, Fu H, Liddington RC
J Biol Chem 273 16305-10 (1998)
PMID: 9632691

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158965 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
14-3-3 protein zeta/delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 245 amino acids
Theoretical weight: 27.78 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P63103 (Residues: 1-245; Coverage: 100%)
Gene name: YWHAZ
Sequence domains: 14-3-3 protein
Structure domains: 14-3-3 domain
R18 PEPTIDE (PHCVPRDLSWLDLEANMCLP) Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 20 amino acids
Theoretical weight: 2.36 KDa
Source organism: Bos taurus
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P65
Unit cell:
a: 95.52Å b: 95.52Å c: 235.36Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.33 0.33 0.39
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

44 review citations

14-3-3 proteins: structure, function, and regulation.
Fu et al. (2000)
43 more

8 mentions without citation

Modulators of 14-3-3 Protein-Protein Interactions.
Stevers et al. (2018)
7 more