› 1afc

X-ray diffraction
2.7Å resolution

STRUCTURAL STUDIES OF THE BINDING OF THE ANTI-ULCER DRUG SUCROSE OCTASULFATE TO ACIDIC FIBROBLAST GROWTH FACTOR

Released:
DOI: 10.2210/pdb1afc/pdb
PDB entry 1afc coloured by chain, front view.
PDB entry 1afc coloured by chain, side view.
PDB entry 1afc coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structural studies of the binding of the anti-ulcer drug sucrose octasulfate to acidic fibroblast growth factor.
Zhu X, Hsu BT, Rees DC
Structure 1 27-34 (1993)
PMID: 7520817

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137304 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Fibroblast growth factor 1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 140 amino acids
Theoretical weight: 15.87 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P03968 (Residues: 16-155; Coverage: 90%)
Gene names: AFGF, FGF1, FGFA, HBGF-1
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

Carbohydrate polymer : NEW Components: GU4, YYJ
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3221
Unit cell:
a: 110.6Å b: 110.6Å c: 172.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.204 not available
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Structural basis for fibroblast growth factor receptor activation.
Mohammadi et al. (2005)
11 more

10 mentions without citation

Wordom: a user-friendly program for the analysis of molecular structures, trajectories, and free energy surfaces.
Seeber et al. (2011)
9 more