› 1ap8

Solution NMR

TRANSLATION INITIATION FACTOR EIF4E IN COMPLEX WITH M7GDP, NMR, 20 STRUCTURES

Released:
DOI: 10.2210/pdb1ap8/pdb
PDB entry 1ap8 coloured by chain, ensemble of 20 models, front view.
PDB entry 1ap8 coloured by chain, ensemble of 20 models, side view.
PDB entry 1ap8 coloured by chain, ensemble of 20 models, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein.
Matsuo H, Li H, McGuire AM, Fletcher CM, Gingras AC, Sonenberg N, Wagner G
Nat Struct Biol 4 717-24 (1997)
PMID: 9302999

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139460 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Eukaryotic translation initiation factor 4E Chain: A
Molecule details ›
Chain: A
Length: 213 amino acids
Theoretical weight: 24.29 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli
UniProt:
  • Canonical: P07260 (Residues: 1-213; Coverage: 100%)
Gene names: CDC33, TIF45, YOL139C
Sequence domains: Eukaryotic initiation factor 4E
Structure domains: RNA Cap, Translation Initiation Factor Eif4e

Ligands and Environments

1 bound ligand:
Ligand M7G 1 x M7G
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

51 review citations

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.
Gingras et al. (1999)
50 more

5 mentions without citation

A normalized root-mean-square distance for comparing protein three-dimensional structures.
Carugo et al. (2001)
4 more