› 1av3

Solution NMR

POTASSIUM CHANNEL BLOCKER KAPPA CONOTOXIN PVIIA FROM C. PURPURASCENS, NMR, 20 STRUCTURES

Released:
DOI: 10.2210/pdb1av3/pdb
PDB entry 1av3 coloured by chain, ensemble of 20 models, front view.
PDB entry 1av3 coloured by chain, ensemble of 20 models, side view.
PDB entry 1av3 coloured by chain, ensemble of 20 models, top view.
Source organism: Conus purpurascens
Primary publication:
Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA.
Scanlon MJ, Naranjo D, Thomas L, Alewood PF, Lewis RJ, Craik DJ
Structure 5 1585-97 (1997)
PMID: 9438859

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157502 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kappa-conotoxin PVIIA Chain: A
Molecule details ›
Chain: A
Length: 27 amino acids
Theoretical weight: 3.28 KDa
Source organism: Conus purpurascens
Expression system: Not provided
UniProt:
  • Canonical: P56633 (Residues: 46-72; Coverage: 54%)
Sequence domains: Conotoxin

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HYP 1 x HYP

Experiments and Validation Details

Entry percentile scores
Refinement method: DYNAMICAL SIMULATED ANNEALING
Expression system: Not provided

Quick links

Citations

13 review citations

The cystine knot motif in toxins and implications for drug design.
Craik et al. (2001)
12 more

7 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
6 more