› 1awv

X-ray diffraction
2.34Å resolution

CYPA COMPLEXED WITH HVGPIA

Released:
DOI: 10.2210/pdb1awv/pdb
PDB entry 1awv coloured by chain, front view.
PDB entry 1awv coloured by chain, side view.
PDB entry 1awv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.
Vajdos FF, Yoo S, Houseweart M, Sundquist WI, Hill CP
Protein Sci 6 2297-307 (1997)
PMID: 9385632

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158773 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase A Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 164 amino acids
Theoretical weight: 17.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62937 (Residues: 2-165; Coverage: 99%)
Gene names: CYPA, PPIA
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like
PEPTIDE FROM THE HIV-1 CAPSID PROTEIN Chains: G, H, I, J, K, L
Molecule details ›
Chains: G, H, I, J, K, L
Length: 6 amino acids
Theoretical weight: 594 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P41
Unit cell:
a: 74Å b: 74Å c: 190.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.358 0.358 0.46
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

10 review citations

Retrovirus restriction factors.
Goff SP. (2004)
9 more