› 1b38

X-ray diffraction
2Å resolution

HUMAN CYCLIN-DEPENDENT KINASE 2

Released:
DOI: 10.2210/pdb1b38/pdb
PDB entry 1b38 coloured by chain, front view.
PDB entry 1b38 coloured by chain, side view.
PDB entry 1b38 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Effects of phosphorylation of threonine 160 on cyclin-dependent kinase 2 structure and activity.
Brown NR, Noble ME, Lawrie AM, Morris MC, Tunnah P, Divita G, Johnson LN, Endicott JA
J Biol Chem 274 8746-56 (1999)
PMID: 10085115

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150313 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 299 amino acids
Theoretical weight: 34 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand ATP 1 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.5
Spacegroup: P212121
Unit cell:
a: 53.333Å b: 71.122Å c: 72.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.18 0.25
Expression system: Spodoptera frugiperda

Quick links

Citations

27 review citations

Protein kinases: evolution of dynamic regulatory proteins.
Taylor et al. (2011)
26 more

21 mentions without citation

Inhibitors of Cyclin-Dependent Kinases: Types and Their Mechanism of Action.
Łukasik et al. (2021)
20 more