› 1cx8

X-ray diffraction
3.2Å resolution

CRYSTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR

Released:
DOI: 10.2210/pdb1cx8/pdb
PDB entry 1cx8 coloured by chain, front view.
PDB entry 1cx8 coloured by chain, side view.
PDB entry 1cx8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the ectodomain of human transferrin receptor.
Lawrence CM, Ray S, Babyonyshev M, Galluser R, Borhani DW, Harrison SC
Science 286 779-82 (1999)
PMID: 10531064

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transferrin receptor protein 1, serum form Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 639 amino acids
Theoretical weight: 71.62 KDa
Source organism: Homo sapiens
Expression system: Cricetinae gen. sp.
UniProt:
  • Canonical: P02786 (Residues: 122-760; Coverage: 84%)
Gene name: TFRC
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 24 x NAG
Ligand SM 24 x SM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 105.4Å b: 216.9Å c: 361.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.243 0.284
Expression system: Cricetinae gen. sp.

Quick links

Citations

37 review citations

Forging a field: the golden age of iron biology.
Andrews NC. (2008)
36 more

35 mentions without citation

Transferrin-mediated cellular iron delivery.
Luck et al. (2012)
34 more