› 1cyz

Solution NMR

NMR STRUCTURE OF THE GAACTGGTTC/TRI-IMIDAZOLE POLYAMIDE COMPLEX

Released:
DOI: 10.2210/pdb1cyz/pdb
PDB entry 1cyz coloured by chain, front view.
PDB entry 1cyz coloured by chain, side view.
PDB entry 1cyz coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Imidazole-imidazole pair as a minor groove recognition motif for T:G mismatched base pairs.
Yang XL, Hubbard RB, Lee M, Tao ZF, Sugiyama H, Wang AH
Nucleic Acids Res 27 4183-90 (1999)
PMID: 10518609

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113566 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*GP*AP*AP*CP*TP*GP*GP*TP*TP*C)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 10 nucleotides
Theoretical weight: 3.06 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand AR1 2 x AR1
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: NOE-RESTRAINED CONJUGATE GRADIENT REFINEMENT IN X-PLOR; FULL MATRIX RELAXATION
Expression system: Not provided

Quick links

Citations

2 review citations

Finding needles in a basestack: recognition of mismatched base pairs in DNA by small molecules.
Granzhan et al. (2014)
1 more

2 mentions without citation

Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.
Munde et al. (2007)
1 more