› 1da5

Solution NMR

Solution structure of a DNA Duplex containing the CIS-PT(NH3)2[D(-GTG-)-N7-(G)-N7(G)N7(G)]Adduct as determined with high field NMR And molecular mechanics/dynamics

Released:
DOI: 10.2210/pdb1da5/pdb
PDB entry 1da5 coloured by chain, ensemble of 2 models, front view.
PDB entry 1da5 coloured by chain, ensemble of 2 models, side view.
PDB entry 1da5 coloured by chain, ensemble of 2 models, top view.
Source organism: Synthetic construct
Primary publication:
The solution structure of a DNA duplex containing the cis-Pt(NH3)2[d(-GTG-)-N7(G),N7(G)] adduct, as determined with high-field NMR and molecular mechanics/dynamics.
van Garderen CJ, van Houte LP
Eur J Biochem 225 1169-79 (1994)
PMID: 7957208

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113661 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(P*CP*TP*CP*TP*AP*GP*TP*GP*CP*TP*CP*AP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 13 nucleotides
Theoretical weight: 3.9 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA (5'-D(P*GP*TP*GP*AP*GP*CP*AP*CP*TP*AP*GP*AP*G)-3') Chain: B
Molecule details ›
Chain: B
Length: 13 nucleotides
Theoretical weight: 4.04 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CPT 1 x CPT
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

2 review citations

Inhibition of transcription by platinum antitumor compounds.
Todd et al. (2009)
1 more