› 1dgg

X-ray diffraction
1.8Å resolution

HUMAN ERYTHROCYTE CATALSE CYANIDE COMPLEX

Released:
DOI: 10.2210/pdb1dgg/pdb
PDB entry 1dgg coloured by chain, front view.
PDB entry 1dgg coloured by chain, side view.
PDB entry 1dgg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.
Putnam CD, Arvai AS, Bourne Y, Tainer JA
J Mol Biol 296 295-309 (2000)
PMID: 10656833

Function and Biology Details

Reaction catalysed: 
2 H(2)O(2) = O(2) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137332 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Catalase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 497 amino acids
Theoretical weight: 56.63 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P04040 (Residues: 5-501; Coverage: 94%)
Gene name: CAT
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand HEM 4 x HEM
2 bound ligands:
Ligand CYN 4 x CYN
Ligand NDP 2 x NDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 83.862Å b: 140.608Å c: 231.591Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.178 0.221

Quick links

Citations

33 review citations

The molecular mechanisms and physiological consequences of oxidative stress: lessons from a model bacterium.
Imlay JA. (2013)
32 more

7 mentions without citation

Crosstalk between JNK and SUMO signaling pathways: deSUMOylation is protective against H2O2-induced cell injury.
Feligioni et al. (2011)
6 more