› 1dsa

Solution NMR

(+)-DUOCARMYCIN SA COVALENTLY LINKED TO DUPLEX DNA, NMR, 20 STRUCTURES

Released:
DOI: 10.2210/pdb1dsa/pdb
PDB entry 1dsa coloured by chain, ensemble of 20 models, front view.
PDB entry 1dsa coloured by chain, ensemble of 20 models, side view.
PDB entry 1dsa coloured by chain, ensemble of 20 models, top view.
Source organism: Synthetic construct
Primary publication:
High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA.
Eis PS, Smith JA, Rydzewski JM, Case DA, Boger DL, Chazin WJ
J Mol Biol 272 237-52 (1997)
PMID: 9299351

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113707 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(*GP*AP*CP*TP*AP*AP*TP*TP*GP*AP*C)-3', 5'-D(*GP*TP*CP*AP*AP*TP*TP*AP*GP*TP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 11 nucleotides
Theoretical weight: 3.36 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA (5'-D(*GP*AP*CP*TP*AP*AP*TP*TP*GP*AP*C)-3', 5'-D(*GP*TP*CP*AP*AP*TP*TP*AP*GP*TP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.35 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DSA 1 x DSA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: RESTRAINED MOLECULAR DYNAMICS
Expression system: Not provided

Quick links

Citations

1 review citation

Inverse Electron Demand Diels-Alder Reactions of Heterocyclic Azadienes, 1-Aza-1,3-Butadienes, Cyclopropenone Ketals, and Related Systems. A Retrospective.
Zhang et al. (2019)
20 other articles

1 mention without citation

Structural evolution of a DNA repair self-resistance mechanism targeting genotoxic secondary metabolites.
Mullins et al. (2021)