› 1eeg

Solution NMR

A(GGGG)A HEXAD PAIRING ALIGMENT FOR THE D(G-G-A-G-G-A-G) SEQUENCE

Released:
DOI: 10.2210/pdb1eeg/pdb
PDB entry 1eeg coloured by chain, ensemble of 10 models, front view.
PDB entry 1eeg coloured by chain, ensemble of 10 models, side view.
PDB entry 1eeg coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
A dimeric DNA interface stabilized by stacked A.(G.G.G.G).A hexads and coordinated monovalent cations.
Kettani A, Gorin A, Majumdar A, Hermann T, Skripkin E, Zhao H, Jones R, Patel DJ
J Mol Biol 297 627-44 (2000)
PMID: 10731417

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113729 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*GP*GP*AP*GP*GP*A)-3') Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 6 nucleotides
Theoretical weight: 1.9 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: described in the cited paper
Expression system: Not provided

Quick links

Citations

13 review citations

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Balasubramanian et al. (2011)
12 more

3 mentions without citation

Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.
Patel et al. (2007)
2 more