› 1ewx

X-ray diffraction
1.7Å resolution

Crystal structure of native tryparedoxin I from Crithidia fasciculata

Released:
DOI: 10.2210/pdb1ewx/pdb
PDB entry 1ewx coloured by chain, front view.
PDB entry 1ewx coloured by chain, side view.
PDB entry 1ewx coloured by chain, top view.
Source organism: Crithidia fasciculata
Primary publication:
Structures of tryparedoxins revealing interaction with trypanothione.
Hofmann B, Budde H, Bruns K, Guerrero SA, Kalisz HM, Menge U, Montemartini M, Nogoceke E, Steinert P, Wissing JB, Flohé L, Hecht HJ
Biol Chem 382 459-71 (2001)
PMID: 11347894

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132146 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 16.39 KDa
Source organism: Crithidia fasciculata
UniProt:
  • Canonical: O96438 (Residues: 2-146; Coverage: 99%)
Gene names: TryX, txnI
Sequence domains: Thioredoxin-like
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P212121
Unit cell:
a: 37.94Å b: 51.39Å c: 71.46Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.168 0.214

Quick links

Citations

11 review citations

Peroxiredoxins.
Hofmann et al. (2002)
10 more

3 mentions without citation

Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential.
Chalmel et al. (2007)
2 more