› 1fsx

X-ray diffraction
2.1Å resolution

THE X-RAY STRUCTURE DETERMINATION OF BOVINE CARBONMONOXY HB AT 2.1 A RESOLUTION AND ITS RELATIONSHIP TO THE QUATERNARY STRUCTURE OF OTHER HB CRYSTAL FORMS

Released:
DOI: 10.2210/pdb1fsx/pdb
PDB entry 1fsx coloured by chain, front view.
PDB entry 1fsx coloured by chain, side view.
PDB entry 1fsx coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The X-ray structure determination of bovine carbonmonoxy hemoglobin at 2.1 A resoultion and its relationship to the quaternary structures of other hemoglobin crystal froms.
Safo MK, Abraham DJ
Protein Sci 10 1091-9 (2001)
PMID: 11369847

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135382 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 141 amino acids
Theoretical weight: 15.08 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P01966 (Residues: 2-142; Coverage: 99%)
Gene name: HBA
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 145 amino acids
Theoretical weight: 15.98 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P02070 (Residues: 1-145; Coverage: 100%)
Gene name: HBB
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

2 bound ligands:
Ligand CMO 4 x CMO
Ligand HEM 4 x HEM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 79.41Å b: 110.63Å c: 65.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.205 0.254

Quick links

Citations

2 review citations

Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property.
Pagare et al. (2022)
1 more

6 mentions without citation

Hemoglobin: Structure, Function and Allostery.
Ahmed et al. (2020)
5 more