› 1fu6

Solution NMR

NMR STRUCTURE OF THE N-SH2 DOMAIN OF THE P85 SUBUNIT OF PI3-KINASE

Released:
DOI: 10.2210/pdb1fu6/pdb
PDB entry 1fu6 coloured by chain, front view.
PDB entry 1fu6 coloured by chain, side view.
PDB entry 1fu6 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site.
Weber T, Schaffhausen B, Liu Y, Günther UL
Biochemistry 39 15860-9 (2000)
PMID: 11123912

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179036 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 111 amino acids
Theoretical weight: 12.87 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q63787 (Residues: 321-431; Coverage: 15%)
Gene name: Pik3r1
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: The structures were energy minimized with MSI DISCOVER.
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases.
Djordjevic et al. (2002)
3 more

1 mention without citation

Reassessing random-coil statistics in unfolded proteins.
Fitzkee et al. (2004)