› 1ihy

X-ray diffraction
3Å resolution

GAPDH complexed with ADP-ribose

Released:
DOI: 10.2210/pdb1ihy/pdb
PDB entry 1ihy coloured by chain, front view.
PDB entry 1ihy coloured by chain, side view.
PDB entry 1ihy coloured by chain, top view.
Source organism: Panulirus versicolor
Primary publication:
Structures of D-glyceraldehyde-3-phosphate dehydrogenase complexed with coenzyme analogues.
Shen YQ, Song SY, Lin ZJ
Acta Crystallogr D Biol Crystallogr 58 1287-97 (2002)
PMID: 12136140

Function and Biology Details

Reaction catalysed: 
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157512 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glyceraldehyde-3-phosphate dehydrogenase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 333 amino acids
Theoretical weight: 35.86 KDa
Source organism: Panulirus versicolor
UniProt:
  • Canonical: P56649 (Residues: 1-333; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 8 x SO4
Ligand APR 4 x APR
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 152.8Å b: 100.35Å c: 128.31Å
α: 90° β: 110.28° γ: 90°
R-values:
R R work R free
0.176 0.176 0.207

Quick links

Citations

2 citation in other articles

The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes.
Buelow et al. (2008)
1 more

2 mentions without citation

Potential Therapeutic Mechanism of Radix Angelicae Biseratae and Dipsaci Radix Herb Pair against Osteoarthritis: Based on Network Pharmacology and Molecular Docking.
Xi et al. (2023)
1 more