› 1ijv

X-ray diffraction
1.2Å resolution

HUMAN BETA-DEFENSIN-1

Released:
DOI: 10.2210/pdb1ijv/pdb
PDB entry 1ijv coloured by chain, front view.
PDB entry 1ijv coloured by chain, side view.
PDB entry 1ijv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of human beta-defensin-1: new insights into structural properties of beta-defensins.
Hoover DM, Chertov O, Lubkowski J
J Biol Chem 276 39021-6 (2001)
PMID: 11486002

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-defensin 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 36 amino acids
Theoretical weight: 3.94 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P60022 (Residues: 33-68; Coverage: 77%)
Gene names: BD1, DEFB1, HBD1
Sequence domains: Beta defensin

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand BR 6 x BR
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P212121
Unit cell:
a: 27.121Å b: 47.243Å c: 53.853Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.157 0.161 0.193
Expression system: Not provided

Quick links

Citations

27 review citations

Antimicrobial peptides: premises and promises.
Reddy et al. (2004)
26 more

17 mentions without citation

Peptides and Peptidomimetics for Antimicrobial Drug Design.
Mojsoska et al. (2015)
16 more