› 1j0s

Solution NMR

Solution structure of the human interleukin-18

Released:
DOI: 10.2210/pdb1j0s/pdb
PDB entry 1j0s coloured by chain, ensemble of 20 models, front view.
PDB entry 1j0s coloured by chain, ensemble of 20 models, side view.
PDB entry 1j0s coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The structure and binding mode of interleukin-18.
Kato Z, Jee J, Shikano H, Mishima M, Ohki I, Ohnishi H, Li A, Hashimoto K, Matsukuma E, Omoya K, Yamamoto Y, Yoneda T, Hara T, Kondo N, Shirakawa M
Nat Struct Biol 10 966-71 (2003)
PMID: 14528293

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171913 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-18 Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 18.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14116 (Residues: 37-193; Coverage: 81%)
Gene names: IGIF, IL18, IL1F4
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

20 review citations

Interleukin-18 and the pathogenesis of inflammatory diseases.
Dinarello CA. (2007)
19 more

13 mentions without citation

Structural Basis of IL-1 Family Cytokine Signaling.
Fields et al. (2019)
12 more