Function and Biology Details
Reactions catalysed:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Thymidylate synthase
- Dihydrofolate reductase domain
- Thymidylate synthase/dCMP hydroxymethylase domain
- Thymidylate synthase/dCMP hydroxymethylase superfamily
- Dihydrofolate reductase-like domain superfamily
- Thymidylate synthase, active site
- Thymidylate synthase/dCMP hydroxymethylase
- Dihydrofolate reductase conserved site
1 more domain
Structure domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146818 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):