› 1lmj

Solution NMR

NMR Study of the Fibrillin-1 cbEGF12-13 Pair of Ca2+ Binding Epidermal Growth Factor-like Domains

Released:
DOI: 10.2210/pdb1lmj/pdb
PDB entry 1lmj coloured by chain, ensemble of 25 models, front view.
PDB entry 1lmj coloured by chain, ensemble of 25 models, side view.
PDB entry 1lmj coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure and dynamics of a calcium binding epidermal growth factor-like domain pair from the neonatal region of human fibrillin-1.
Smallridge RS, Whiteman P, Werner JM, Campbell ID, Handford PA, Downing AK
J Biol Chem 278 12199-206 (2003)
PMID: 12511552

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152940 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibrillin-1 Chain: A
Molecule details ›
Chain: A
Length: 86 amino acids
Theoretical weight: 9.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35555 (Residues: 1069-1154; Coverage: 3%)
Gene names: FBN, FBN1
Sequence domains: Calcium-binding EGF domain
Structure domains: Laminin

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

11 review citations

The molecular genetics of Marfan syndrome and related disorders.
Robinson et al. (2006)
10 more

8 mentions without citation

Rare and common variants in extracellular matrix gene Fibrillin 2 (FBN2) are associated with macular degeneration.
Ratnapriya et al. (2014)
7 more