› 1m2c

Solution NMR

THREE-DIMENSIONAL STRUCTURE OF ALPHA-CONOTOXIN MII, NMR, 14 STRUCTURES

Released:
DOI: 10.2210/pdb1m2c/pdb
PDB entry 1m2c coloured by chain, ensemble of 14 models, front view.
PDB entry 1m2c coloured by chain, ensemble of 14 models, side view.
PDB entry 1m2c coloured by chain, ensemble of 14 models, top view.
Source organism: Conus magus
Primary publication:
A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors.
Cartier GE, Yoshikami D, Gray WR, Luo S, Olivera BM, McIntosh JM
J Biol Chem 271 7522-8 (1996)
PMID: 8631783

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157506 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-conotoxin MII Chain: A
Molecule details ›
Chain: A
Length: 17 amino acids
Theoretical weight: 1.72 KDa
Source organism: Conus magus
Expression system: Not provided
UniProt:
  • Canonical: P56636 (Residues: 49-64; Coverage: 34%)
Sequence domains: Alpha conotoxin precursor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DISTANCE GEOMETRY, ITERATIVE RELAXATION MATRIX APPROACH, SIMULATED ANNEALING
Expression system: Not provided

Quick links

Citations

52 review citations

Neuronal nicotinic receptors: from structure to pathology.
Gotti et al. (2004)
51 more

5 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
4 more