› 1mhq

X-ray diffraction
2.2Å resolution

Crystal Structure Of Human GGA2 VHS Domain

Released:
DOI: 10.2210/pdb1mhq/pdb
PDB entry 1mhq coloured by chain, front view.
PDB entry 1mhq coloured by chain, side view.
PDB entry 1mhq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket.
Zhu G, He X, Zhai P, Terzyan S, Tang J, Zhang XC
FEBS Lett 537 171-6 (2003)
PMID: 12606052

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193826 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribosylation factor-binding protein GGA2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 148 amino acids
Theoretical weight: 17.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UJY4 (Residues: 25-172; Coverage: 24%)
Gene names: GGA2, KIAA1080
Sequence domains: VHS domain
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 62.86Å b: 68.11Å c: 74.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.223 0.267
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The ESCRT complexes: structure and mechanism of a membrane-trafficking network.
Hurley et al. (2006)
4 more

1 mention without citation

Do GGA adaptors bind internal DXXLL motifs?
Doray et al. (2012)