› 1mk3

Solution NMR

SOLUTION STRUCTURE OF HUMAN BCL-W PROTEIN

Released:
DOI: 10.2210/pdb1mk3/pdb
PDB entry 1mk3 coloured by chain, ensemble of 10 models, front view.
PDB entry 1mk3 coloured by chain, ensemble of 10 models, side view.
PDB entry 1mk3 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix.
Denisov AY, Madiraju MS, Chen G, Khadir A, Beauparlant P, Attardo G, Shore GC, Gehring K
J Biol Chem 278 21124-8 (2003)
PMID: 12651847

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187782 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bcl-2-like protein 2 Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 19.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q92843 (Residues: 2-171; Coverage: 88%)
Gene names: BCL2L2, BCLW, KIAA0271
Sequence domains:
Structure domains: Blc2-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

24 review citations

The BCL-2 protein family: opposing activities that mediate cell death.
Youle et al. (2008)
23 more

5 mentions without citation

The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane.
Luna-Vargas et al. (2016)
4 more