› 1ne6

X-ray diffraction
2.3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132578 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed Chain: A
Molecule details ›
Chain: A
Length: 283 amino acids
Theoretical weight: 31.88 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00514 (Residues: 95-377; Coverage: 75%)
Gene name: PRKAR1A
Sequence domains: Cyclic nucleotide-binding domain
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand SP1 2 x SP1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P6522
Unit cell:
a: 87.4Å b: 87.4Å c: 178.7Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.211 0.211 0.241
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Capturing cyclic nucleotides in action: snapshots from crystallographic studies.
Rehmann et al. (2007)
3 more

8 mentions without citation

The cAMP binding domain: an ancient signaling module.
Berman et al. (2005)
7 more